OsmoPRO® Multi-Sample Micro-Osmometer

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OsmoPRO® Multi-Sample Micro-Osmometer

Supporting efficient workflows for mid- to high-volume clinical chemistry labs, the OsmoPRO features a convenient carousel design that handles up to 20 samples, an intuitive touchscreen interface, and industry-leading performance. Simple, reliable, and efficient, the OsmoPRO delivers accurate and precise analysis of patient samples for maximum productivity.

Highlighted features:
  • Low sample volume requirements
  • Supports CAP, CLIA, and HIPAA compliance
  • Gold-standard freezing point technology




Great for mid to high-throughput labs that test urine, plasma, serum and stool osmolality. The OsmoPRO helps maximise productivity and keep the busiest clinical chemistry labs in compliance.



At the heart of the OsmoPRO system is a large 7” touchscreen display seamlessly integrated with intuitive and functional software control capabilities. Operating an Advanced Osmometer has never been easier.


OsmoPRO features an easy to use carousel design which allows batch processing of up to 20 samples. Simply load it up, press start and walk away. Let OsmoPRO do the rest.


Requiring only 20 µL sample, OsmoPRO is ideal for applications where the sample quantity is limited.


With a 90 second test time and an operating range of 0-2000 mOsm, OsmoPRO provides fast and accurate osmolality test results while improving laboratory efficiency.


With a simple drop in paper design, OsmoPRO allows for easy printout and archiving of test results. Previous test results can also be reprinted from the results stored in system memory.


OsmoPRO features multi-language operation, on board statistical analysis, and an internal memory of the last 1000 samples.


The OsmoPRO connects easily to LIS and data management systems via Ethernet connectivity. Multiple USB ports provide the ability to easily export data and other diagnostic log files. Future software upgrades are also available via a USB.


OsmoPRO provides a true 3-point calibration spanning the entire operating range to assure accuracy for routine testing.


Freezing point determinations are the industry gold standard, and Advanced Osmometers provide class leading performance guaranteed.


You can purchase any Advanced Instruments osmometer with complete confidence as every instrument is backed by a knowledgeable, experienced, and responsive customer support team.

Technical Specifications

Specimen typeBody fluids
Sample volume20μL
Test time90 Seconds
Sample capacityUp to 20 samples
UnitmOsm/kg H2O
Resolution1 mOsm/kg H2O
Range0 to 2000 mOsm/kg H2O
Accuracy20 to 400 mOsm/kg H2O: ≤ 3 mOsm/kg H2O from nominal value(1 SD)
> 400 to < 2000 mOsm/kg H2O: ≤ 0.75% from normal value (1 SD)
precision2(within run )0 to 400 mOsm/kg H2O: standard deviation ≤ 3 mOsm/kg H2O
> 400 to < 2000 mOsm/: CV ≤ 0.75%
Temperature effects3Less than 1 mOsm/kg H2O per 5°C (9°F)ambient temperature change
communicationOn-board printer, Integrated 2D-barcode Scanner, USB 2.0 Type A (3), USB 2.0 Type B (1), Ethernet port(1)
Supported languagesSimple Chinese, Czech, Danish, English, French, German, Greek, Italian, Japanese, Korean, Portuguese, Russian, Slovak, Spanish, Swedish, Turkish
Storage temperature-40°C to +45°C (-40°F to +113°F)
Electrical voltage100 to 240 VAC (50/60 Hz)
Power consumption60 Watts
Dimensions (D x W x H)37 cm x 25 cm x 44 cm (14″ x 10″ x 17.5″)
Net weight13.2 kg (29 lbs)
Shipping weight19.1 kg (42 lbs)
WarrantyOne-year limited warranty on workmanship and all parts
  1. Subject to change
  2. Performance at Reference Conditions: 20°C to 25°C (68°F to 77°F); 40 to 60%
    relative humidity
  3. Operating Conditions: Temperature 18°C to 35°C (64°F to 95°F); 30 to 80%
    relative humidity (non-condensing)

Associated Products

Osmometer Calibration Standards

50, 850 & 2000 mOsm
10 x 2mL Ampules

Osmolality Linearity Set

100-2,000 mOsm
5x2x5mL Ampules

Osmometer Calibration Standards & Reference Solutions

SKC-OsmoPROConvenience Kit (Includes: 202825, 3MA005, 3MA029, 3MA085, 3MA200, 3LA028, FLA835, 202840, 240821, 202850, 3MA028, 3LA085)
3MA029Clinitrol 290 Reference Solution, 10×2 mL AmpulesView
3MA00550 mOsm Calibration Standard, 10×2 mLView
3MA085850 mOsm Calibration Standard, 10×2 mLView
3MA2002000mOsm Calibration Standard, 10×2 mL AmpulesView
3LA028Osmolality Linearity Set 100-2,000 mOsm 5x2x5 mLView

Supplies and Accessories

202825Disposable Sample Tubes, Box 500
202840Probe Wiper Discs, Box 50
24082020-Microliter Pipette
800097Pipette Tips (960 pieces)
202850Swab Cleaner Kit
FLA835Thermal Printer Paper, 5 rolls

Osmometer Control Solutions

3MA028Protinol 3-Level Osmometer Control, 3x3x3 mL
3LA085Renol 2-Level Osmometer Control, 2x4x3 mL

Clinical Services

Protect your investment with an Advanced Care service agreement from Advanced Instruments. Take the worry out of service costs and have total peace of mind knowing that your instrument is covered.


Medical lab instruments that deliver accuracy and efficiency

For laboratories seeking premium, reliable osmometers that meet their everyday needs for workflow efficiency, patient results security and integrity, connectivity, quality control, and compliance with CAP and CLIA guidelines , Advanced Instruments Osmometers are the right choice.

Keep your labs running smoothly and in compliance with osmometers that use the industry preferred freezing point depression method to provide accurate patient results.

See all osmometers

Streamline workflow, save money and improve the quality and consistency of your bacterial cultivation. Automatically and easily create exact, repeatable environments to keep clinical labs productive so patients can potentially get treated faster and spend less time in the hospital.

With the Anoxomat anaerobic jar system by Advanced Instruments, you’ll get the flexibility to simultaneously maintain multiple types of anaerobic, micro-aerophilic, and capnophilic environments on your benchtop for fast and reliable bacterial growth and larger colonies.

The Anoxomat system speeds sample processing with the ability to move plates into and out of the micro-environment within minutes instead of the hours it takes with full-sized vacuum systems and anaerobic chambers. Everyone in the lab can accomplish more with Anoxomat.

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Comparison Guide

All models support:
  • HIPAA, CAP and CLIA compliance

Workflow Features
Best for labs with daily sample processing needs of:>10/day>10/day1-10/day
Sample volume100 µL20 µL20 µL
Sample introductionAutomated liquid handling sample cupSample cupOne-step direct
Operating range (mOsm/kg H2O)0 – 4,0000 – 2,0000 – 2,000
Test time (seconds)1809090
Compliance Support Features
Supports CAP & CLIA compliance
Supports HIPAA compliance
Instrument Features
Integrated barcode scanner
On-board printer
Multi-language touchscreen display
User name & password compatibility
Multi-sample capacity
Automated cleaning between samples
Automated sample pipetting
Temperature control methodDry cooling

(No heat-transfer fluid)

Dry cooling

(No heat-transfer fluid)

Dry cooling

(No heat-transfer fluid)

Data Management Features
LIS Connectivity
Part #A2OOsmoPROOsmo1

  1. Printer (dot-matrix) sold separately
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Educational Resources


OsmoPRO® Multi-Sample Micro-Osmometer


What is Osmolality?

Application Note

The Value of Osmolality Testing in Clinical Chemistry

We are open and continue to provide essential lab supplies during the COVID-19 pandemic. Answers to your FAQ’s can be found here.

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