Osmo1® Single-Sample Micro-Osmometer | AI

Looking for biotech solutions?

Osmo1® Single-Sample Micro-Osmometer

With the Osmo1 Single-Sample Micro-Osmometer, we’ve bundled together accurate and reliable osmolality measurement with ease-of-use for efficient patient sample analysis. Easily maintain regulatory compliance while ensuring the security and integrity of patient data with the Osmo1. Best for labs that process 10 or fewer samples per day or prefer a direct-draw instrument.

Highlighted features:
  • Gold-standard freezing point depression method technology
  • Low sample volume requirements
  • Supports CAP, CLIA, and HIPAA compliance


Industry Applications


Great for smaller clinical labs that test urine, plasma, serum and stool osmolality. The Osmo1 combines easy to use features and data management security options that help you stay in compliance.



Simply aspirate sample and load the sampler into the Osmo1.


The Osmo1 is easy-to-use with an intuitive, color-coded menu-driven operating system, with multi-language capability.


Requiring only 20 µL of sample, Osmo1 is ideal for sample limited applications.


With a simple drop-in paper design, Osmo1 allows for easy printing and archiving of test results.


The built-in proximity sensor enables traceable sample identification and reduces transcription errors.


Osmo1 offers the flexibility of a 2- or 3-point calibration to satisfy CLIA calibration verification requirements. The system is also factory-calibrated and ready-to-use, requiring recalibration only if quality control is out of specification or after maintenance.


Osmo1 calculates sample statistics instantly, can issue warnings when quality control is out of range, and allows tracking of quality control data over time with an exportable Levey-Jennings chart.


The Osmo1 offers password protected user accounts and the ability to link sample ID and user ID to test results, for improved traceability. The system also stores the last 1,000 test records and 10,000 events for audit control.


The Osmo1 connects easily to LIS and data management systems via Ethernet connectivity. Multiple USB ports provide the ability to easily export data.


Osmo1 utilizes the industry-preferred freezing point depression method to accurately and precisely determine osmolality.


You can purchase any Advanced Instruments osmometer with complete confidence as every instrument is backed by a knowledgeable, experienced, and responsive customer support team.

Technical Specifications

Specimen typeBody fluids
Sample volume20 ± 1μL
Test time90 Seconds
Sample capacitySingle sample
UnitmOsm/kg H2O
Resolution1 mOsm/kg H2O
Sample throughputcan process 20 samples in less than 1 hour
Range0 to 2000 mOsm/kg H2O
Accuracy20 to 400 mOsm/kg H2O: mean value ≤ 2 mOsm/kg H2O from nominal value(1 SD)
> 400 to < 1500 mOsm/kg H2O: ≤ 0.5% mOsm/kg H2O from normal value (1 SD)
> 1500 to 2000 mOsm/kg H2O ≤ 1% mOsm/kg H2O from normal value (1 SD)
precision2(within run) 0 to 400 mOsm/kg H2O: standard deviation ≤ 2 mOsm/kg H2O
> 400 to < 1500 mOsm/kg H2O: coefficient of variation ≤ 0.5% mOsm/kg H2O
> 1500 to < 2000 mOsm/kg H2O: coefficient of variation ≤ 1% mOsm/kg H2O
Temperature effects3Less than mOsm/kg H2O per 5°C (9°F) ambient temperature change
CommunicationOnboard printer, USB 2.0 Type A port(2), USB 2.0 Type B Port(1), Ethernet 10/100, RJ45 Connector port(1)
Supported languagesSimple Chinese, Czech, Danish, English, French, German, Greek, Italian, Japanese, Korean, Portuguese, Russian, Slovak, Spanish, Swedish, Turkish
Storage temperature-20°C to +45°C (-4°F to +113°F)
Electrical voltage100 to 240 VAC (50/60 Hz)
Power consumption60 Watts
Dimensions (D x W x H)38 cm x 36 cm x 38 cm (15″ x 14″ x 15″)
Net weight6.0 kg (13.3 lbs)
Shipping weight11.4 kg (25 lbs)
WarrantyOne-year limited warranty on workmanship and all parts except glass, Plastic, and part warranted by their makers
  1. Subject to change
  2. Accuracy and precision (within run) specifications apply to Advanced Instruments standards
    and reference solutions. Performance at Reference Conditions: 20°C to 25°C (68°F to 77°F);
    40 to 60% relative humidity
  3. Operating Conditions: Temperature 18°C to 35°C (64°F to 95°F); 5 to 80% relative humidity
  4. Dimensions when Micro-Sample Test Kit is on the instrument

Osmometer Calibration Standards and Reference Solutions

SKC-Osmo1Convenience Kit (Includes: 133800, 3MA005, 3MA029, 3MA085, 3MA200, 3LA028, FLA835, 3MA028, 3LA085)
3MA029Clinitrol 290 Reference Solution, 10×2 mL AmpulesView
3MA00550 mOsm Calibration Standard, 10×2 mLView
3MA085850 mOsm Calibration Standard, 10×2 mLView
3MA2002000mOsm Calibration Standard, 10×2 mL AmpulesView

Supplies & Accessories

133800Micro-Sample Test Kit: 500 chamber cleaners, 500 sampler tips, 1 plunger wire (Replaces 3MA800 – Sample Tips and Chamber Cleaners, 500/box)
3M0828APlunger Wire, 1 per order (Replaces 3M0828- Plunger Wires, set of 2. Please note: A plunger wire is included in every 133800 and TECH500 Micro-Sample Test Kit box.)
3M0825Ease-Eject 20-Microliter Sampler
3M0827Sampler Calibration Key
FLA835Thermal Printer Paper

Osmometer Control Solutions

3MA028Protinol 3-Level Osmometer Control, 3x3x3 mLView
3LA085Renol 2-Level Osmometer Control, 2x4x3 mLView

Clinical Services

Protect your investment with an Advanced Care Service agreement from Advanced Instruments. Take the worry out of service costs and have total peace of mind knowing that your osmometer is covered


Medical lab instruments that deliver accuracy and efficiency

For laboratories seeking premium, reliable osmometers that meet their everyday needs for workflow efficiency, patient results security and integrity, connectivity, quality control, and compliance with CAP and CLIA guidelines , Advanced Instruments Osmometers are the right choice.

Keep your labs running smoothly and in compliance with osmometers that use the industry preferred freezing point depression method to provide accurate patient results.

See all osmometers

Streamline workflow, save money and improve the quality and consistency of your bacterial cultivation. Automatically and easily create exact, repeatable environments to keep clinical labs productive so patients can potentially get treated faster and spend less time in the hospital.

With the Anoxomat anaerobic jar system by Advanced Instruments, you’ll get the flexibility to simultaneously maintain multiple types of anaerobic, micro-aerophilic, and capnophilic environments on your benchtop for fast and reliable bacterial growth and larger colonies.

The Anoxomat system speeds sample processing with the ability to move plates into and out of the micro-environment within minutes instead of the hours it takes with full-sized vacuum systems and anaerobic chambers. Everyone in the lab can accomplish more with Anoxomat.

See all Anaerobic Jar Systems

Related Articles

Busy labs often look to automation to ensure timely sample processing, but analyzing CSF samples – especially those at clinically relevant low cell counts – can be time-consuming and challenging. For labs that want to improve results consistency and turnaround time, there’s an Advanced Solution that meets this need with GloCyte.

Our CSF cell counter automates handling of all CSF samples, detecting down to 1 cell/µL and delivering total nucleated cell (TNC) and red blood cell (RBC) results in less than 5-minutes using only 30 µL per test, GloCyte gives labs a reliable and efficient method for automating analysis of all CSF specimens.

See all CSF Cell Counting products


  1. Malenke, K. Cerebral Spinal Fluid Testing: Current methods for CSF analysis and new cell count technology. Advance for the Administrators of the Laboratory. December 2016. Vol. 25(12):p 16.

Bring accurate and reliable total and direct neonatal bilirubin testing to any facility with the BR2 Bilirubin Stat Analyzer and Bilirubin Test Kit. The compact, portable design easily fits into any facility, whether it is a dedicated medical lab or a pediatrician’s office, and the low 30 µL sample volume requirement facilitates analysis of samples from neonates.

See all Neonatal Bilirubin Testing products

Comparison Guide

All models support HIPAA, CAP & CLIA compliance

Workflow Features
Best for labs with daily sample processing needs of:>10/day>10/day1-10/day
Sample volume100 µL20 µL20 µL
Sample introductionAutomated liquid handlingSample cupOne-step direct sampling
Operating range (mOsm/kg H2O)0 – 4,0000 – 2,0000 – 2,000
Test time (seconds)1809090
Compliance Support Features
Supports CAP & CLIA compliance
Supports HIPAA compliance
Instrument Features
Integrated barcode scanner
On-board printer
Multi-language touchscreen display
Username & password compatibility
Multi-sample capacity
Automated cleaning between samples
Automated sample pipetting
Temperature control methodDry cooling (No heat-transfer fluid)Dry cooling (No heat-transfer fluid)Dry cooling (No heat-transfer fluid)
Data Management Features
LIS Connectivity
Part #A2OOsmoPROOsmo1
Download Chart as PDF

  1. Printer (dot-matrix) sold separately
Learn More
Request Pricing
Learn More
Request Pricing
Learn More
Request Pricing

Educational Resources


Osmo1® Single-Sample Micro-Osmometer


Advantages of Freezing Point Depression

Application Note

The Value of Osmolality Testing

We are open and continue to provide essential lab supplies during the COVID-19 pandemic. Answers to your FAQ’s can be found here.

Read More